It is defined as the amount of damage seen in the sperm's DNA. i.e. the amount of abnormal genetic material present within the sperm cell, which in turn may be a reason for male subfertility, IVF failure and miscarriage. One must consider the impact of DNA damage on the sperm because half of the DNA in the offspring comes from the father’s side.
Sperm DNA fragmentation
Every healthy semen has some amount of fragmented DNA sperm but it is found to be higher in infertile men. Men who have poor semen parameters are more prone to have high sperm DNA fragmentation, but high sperm DNA fragmentation can also be found in men with normal semen parameters, and the reason for their infertility is usually given as unexplained infertility.
Sperm DNA fragmentation is a condition in which the genetic material within the sperm is damaged, leading to reduced fertility or infertility. The fragmentation of DNA in sperm can cause issues in embryo development, low fertilization rates, and even miscarriages. It is estimated that up to 30% of infertility cases may be caused by sperm DNA fragmentation.
Sperm DNA Fragmentation Test:
A sperm DNA fragmentation test is a diagnostic tool used to measure the level of DNA damage in a man's sperm. The test is performed using a sample of semen, which is analyzed under a microscope. The sample is then treated with a dye that binds to damaged DNA, making it easier to identify and count.
DNA Fragmentation Index of Sperm:
The DNA fragmentation index (DFI) of sperm is a measure of the percentage of sperm with damaged DNA in a semen sample. It is calculated by counting the number of sperm with fragmented DNA and dividing it by the total number of sperm in the sample. The resulting percentage is the DFI of the semen sample.
The DFI of sperm is considered a critical parameter in assessing male fertility potential. A higher DFI indicates a higher level of DNA damage in the sperm, which can lead to infertility or subfertility. A DFI of 30% or higher is generally considered abnormal and may require further testing or treatment.
Sperm DNA Fragmentation Test Price In India:
The price of a sperm DNA fragmentation test in India can vary depending on the location and laboratory performing the test, but it typically ranges from INR 7,000 to INR 25,000.
In conclusion, sperm DNA fragmentation is a common cause of infertility in men, affecting up to 30% of infertility cases. A sperm DNA fragmentation test is a diagnostic tool that measures the level of DNA damage in a man's sperm. The DNA fragmentation index (DFI) of sperm is a critical parameter in assessing male fertility potential. A higher DFI indicates a higher level of DNA damage in the sperm, which can lead to infertility or subfertility. The cost of the test may vary, but it can be a crucial tool in diagnosing and treating male infertility. If you suspect that sperm DNA fragmentation may be affecting your fertility, speak with a healthcare provider to determine if a sperm DNA fragmentation test is right for you.
Medicover Fertility provides a comprehensive approach to treating sperm DNA fragmentation, including personalized treatment plans, cutting-edge technology, and experienced fertility specialists, ensuring the highest chances of a successful pregnancy.
